反应详情

温度

0 °C

To a stirred slurry of 1.44 g (36 mmol) sodium hydride, obtained as a 60% dispersion in mineral oil, in 45 mL anhydrous THF, at 0° C., was added dropwise 6.48 g (33.75 mmol) ethyl benzoyl acetate. The resulting slurry was stirred at 0° C. for 0.5 hr, upon which time was added dropwise the entire sample of 2-bromo-1-cyclohexyl-ethanone obtained in Step 1. The reaction was stirred at room temperature for 24 hr and poured into 0.4 L brine. The brine was shaken with ethyl acetate twice and the combined organic extracts were dried over MgSO4 and concentrated to afford 14.37 g (45.4 mmol, >100% yield) of 2-benzoyl-4-cyclohexyl-4-oxo-butyric acid ethyl ester. The product was used in the next step without further purification.

1. stirringThe reaction was stirred at room temperature for 24 hr
2. dry with materialthe combined organic extracts were dried over MgSO4
3. concentrationconcentrated