反应详情

Combine 7-bromo-5H-furo[3,2-c]pyridin-4-one (16.16 g, 75.5 mmol), dichloroethane (160 mL), and phosphorus oxybromide (100 g, 348.8 mmol) and heat at reflux for about 2 hours. Cool to room temperature and pour the reaction mixture into ice water (1 L). Adjust the pH to 8 with SN NaOH, extract into dichloromethane, wash with brine, dry over magnesium sulfate, filter, and concentrate. Purification by flash chromatography, eluting with hexane:ethyl acetate gives the title compound as a white solid.

1. temperatureat reflux for about 2 hours
2. extractionextract into dichloromethane
3. washwash with brine
4. dry with materialdry over magnesium sulfate
5. filtrationfilter
6. concentrationconcentrate
7. customPurification by flash chromatography
8. washeluting with hexane