Hydrochloric Acid → HCID 178479673, compound

HRID 1725501Notes

Reaction equation

HRID 1725501 reaction equation
[F:1][C:2]1[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5].[ClH:33]>C(O)C>[ClH:33].[F:1][C:2]1[C:28]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178519567HCID 178519567, compound

Product 1

HCID 178479673HCID 178479673, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

19.8 g of 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine (Example 44) was suspended in 200 ml of ethanol, and aqueous hydrogen chloride solution(1.0 M, 44.1 ml) was added thereto. The reaction mixture was stirred at room temperature for 1 hour and then evaporated. The resulting residue was solidified with 200ml of heptane, evaporated and dried to give 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine hydrochloride.

Workup

  1. customevaporated
  2. customevaporated
  3. customdried

Sources & evidence

ORD record
ord-1925a3077c7c4b1a8865b7e6e4cbffb4
Source dataset
uspto-grants-2009_02
Patent number
US07491720B2

Reaction notes

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