1,4-Dioxane hydrochloride → 1-(2-Fluoro-3-(trifluoromethyl)benzoyl)piperazine hydrochloride

HRID 1725510Notes

Reaction equation

HRID 1725510 reaction equation
[F:1][C:2]1[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=[O:5].[ClH:27].O1CCOCC1>CO>[ClH:27].[F:1][C:2]1[C:22]([C:23]([F:26])([F:24])[F:25])=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57562617Tert-butyl 4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazine-1-carboxylate

Product 1

HCID 686783581-(2-Fluoro-3-(trifluoromethyl)benzoyl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 7.74 g of tert-butyl 4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazine-1-carboxylate and 10 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 20 ml) followed by stirring at room temperature for 4 hours. The reaction mixture was concentrated in vacuo to give the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-65323530a0264d9a8cb0f1fc33e868ea
Source dataset
uspto-grants-2009_02
Patent number
US07491720B2

Reaction notes

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