1,4-Dioxane hydrochloride → 1-(2-Fluoro-3-(trifluoromethyl)benzoyl)piperazine hydrochloride

Participants

Reaction Steps

To a mixture of 7.74 g of tert-butyl 4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazine-1-carboxylate and 10 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 20 ml) followed by stirring at room temperature for 4 hours. The reaction mixture was concentrated in vacuo to give the title compound.

Provenance & Evidence