4-Toluenesulfonyl chloride → HCID 19970200, compound

HRID 1725555Notes

Reaction equation

HRID 1725555 reaction equation
[S:1](Cl)([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].[NH:12]1[CH2:17][CH2:16][CH:15]([CH2:18][OH:19])[CH2:14][CH2:13]1>>[CH3:8][C:7]1[CH:9]=[CH:10][C:4]([S:1]([O:19][CH2:18][CH:15]2[CH2:16][CH2:17][N:12]([S:1]([C:4]3[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=3)(=[O:3])=[O:2])[CH2:13][CH2:14]2)(=[O:3])=[O:2])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 4207714-Piperidinemethanol

Product 1

HCID 19970200HCID 19970200, compound

Procedure

Reaction of tosyl chloride and piperidin-4-yl-methanol as described in Preparation 1 gave the desired compound, (1-tosylpiperidin-4-yl)methyl 4-methylbenzenesulfonate, which was used without further purification.

Workup

  1. customas described in Preparation 1

Sources & evidence

ORD record
ord-ff4555afa9cd422c9f4971578f8c3bd9
Source dataset
uspto-grants-2009_02
Patent number
US07491727B2

Reaction notes

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