Potassium Carbonate → HCID 57562528, compound

HRID 1725621Notes

Reaction equation

HRID 1725621 reaction equation
FC(F)(F)C([NH:5][C@H:6]1[CH2:10][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:7]1=[O:21])=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[NH2:5][C@H:6]1[CH2:10][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([CH2:17][CH:18]([CH3:19])[CH3:20])[C:7]1=[O:21]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86616776HCID 86616776, compound

Product 1

HCID 57562528HCID 57562528, compoundYield 92.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of cis-2,2,2-trifluoro-N-(1-isobutyl-2-oxo-5-phenylpyrrolidin-3-yl)acetamide (50.0 mg, 0.152 mmol) in methanol (3 mL) and water (1 mL) was added potassium carbonate (63.1 mg, 0.447 mmol). After 27 hours, the reaction solution was concentrated, and worked up with methylene chloride and water. The organic extracts were dried over sodium sulfate, filtered and concentrated to produce the title compound (32.7 mg). MS 233 (M+1).

Workup

  1. concentrationthe reaction solution was concentrated
  2. dry with materialThe organic extracts were dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-659521b7ac37410090dd97140de200b0
Source dataset
uspto-grants-2009_02
Patent number
US07491713B2

Reaction notes

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