Trifluoroacetic acid → 1-Piperidin-4-ylimidazolidine-2,4-dione

HRID 1725642Notes

Reaction equation

HRID 1725642 reaction equation
FC(F)(F)C(O)=O.[O:8]=[C:9]1[NH:13][C:12](=[O:14])[CH2:11][N:10]1[CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1>ClCCl>[NH:18]1[CH2:17][CH2:16][CH:15]([N:10]2[CH2:11][C:12](=[O:14])[NH:13][C:9]2=[O:8])[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57428924Tert-butyl 4-(2,4-dioxoimidazolidin-1-yl)piperidine-1-carboxylate

Product 1

HCID 574289231-Piperidin-4-ylimidazolidine-2,4-dione

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (0.300 mL) was added to a solution of tert-butyl 4-(2,4-dioxoimidazolidin-1-yl)piperidine-1-carboxylate (32 mg, 0.113 mmol) in dichloromethane (1 mL). After 4 h, the reaction was concentrated to give the title compound. MS 184.04 (M+1).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-38c6a7cdd8f24b349f8ead87f513bae4
Source dataset
uspto-grants-2009_02
Patent number
US07491713B2

Reaction notes

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