Ammonium Chloride → (4-Aminophenyl)-4-thiomorpholinylmethanone

HRID 1725692Notes

Reaction equation

[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O.[NH4+].[Cl-]>C(O)C.O.[Fe]>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([C:8]([N:10]2[CH2:11][CH2:12][S:13][CH2:14][CH2:15]2)=[O:9])=[CH:6][CH:5]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a stirred solution of 4-(4-nitrobenzoyl)thiomorpholine (1.26 g, 5 mmol) in ethanol (80 mL) and water (20 mL) was added NH4Cl (2.65 g) and heated to 80° C. To this heterogeneous reaction mixture at 80° C. was added iron powder (2.75 g) portion wise manner under a vigorous stirring in nitrogen atmosphere and the stirring was continued for 2 h. The reaction mixture was filtered through a Celite pad when hot and washed the pad with methanol. The filtrate was concentrated, diluted with water, extracted with CH2Cl2 (3×75 mL), dried (Na2SO4), filtered and concentrated. Finally dried under high vacuum to afford 1.11 g (100%) of the 4-(4-aminobenzoyl)thiomorpholine. 1H NMR (CDCl3, 300 MHz): δ 7.21 (d, 2H, J=8.4 Hz), 6.64 (d, 2H, J=8.1 Hz), 3.86 (br s, 6H), 2.64 (t, 4H, J=4.5 Hz); LCMS (m/z): 223 (MH+).

Workup

filtrationThe reaction mixture was filtered through a Celite pad when hot
washwashed the pad with methanol
concentrationThe filtrate was concentrated
additiondiluted with water
extractionextracted with CH2Cl2 (3×75 mL)
dry with materialdried (Na2SO4)
filtrationfiltered
concentrationconcentrated
customFinally dried under high vacuum

Sources & evidence

ORD record: ord-8ae250a05ca8452e8f2bb2d56b017f66
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07491732B2

Reaction notes

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