Hydrochloric Acid → 2-Methyl-2-(4-nitrophenoxy)propanoic acid

HRID 1725702Notes

Reaction equation

HRID 1725702 reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][C:9]([CH3:15])([CH3:14])[C:10]([O:12]C)=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].Cl>CO.O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:15])([CH3:14])[C:10]([OH:12])=[O:11])=[CH:16][CH:17]=1)([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57562956Methyl 2-methyl-2-(4-nitrophenoxy)propanoate

Product 1

HCID 1769302-Methyl-2-(4-nitrophenoxy)propanoic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Methyl 2-(4-nitrophenoxy)isobutyrate was dissolved in methanol (50 mL) and water (50 mL). Sodium hydroxide (5 g) was added. The solution was stirred at rt for 30 min, then acidified with 1N HCl aq. to pH ˜3. The aq. Solution was extracted with ethyl acetate (2×100 mL). The organic layers were evaporated to give 2-(4-nitrophenoxy)isobutyric acid.

Workup

  1. extractionThe aq. Solution was extracted with ethyl acetate (2×100 mL)
  2. customThe organic layers were evaporated

Sources & evidence

ORD record
ord-ac61f2d015f944ad8d98d298c06cfab1
Source dataset
uspto-grants-2009_02
Patent number
US07491732B2

Reaction notes

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