HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(1H-Imidazol-2-yl)piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate | HCID 17840015 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1H-Imidazol-2-yl)piperidine dihydrochloride | HCID 13281191 | — |
Reaction Steps
A solution of tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate (5.5 g) in methanol was saturated with HCl and the mixture was left standing overnight. Evaporation give the product in quantitative yield. 1H NMR (400 MHz, D2O): 7.29 (s, 2H), 3.51 (br. d, J=13 Hz, 2H), 3.47-3.40 (m, 1H), 3.12 (br. t, J=13 Hz, 2H), 2.29 (br. d, J=14 Hz, 2H), 2.04-1.92 (m, 21).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491737B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-73dc8929c73247ff81ff4ce59d50f92a |
| Source note | uspto-grants-2009_02 |