Hydrochloric Acid → 4-(1H-Imidazol-2-yl)piperidine dihydrochloride

HRID 1725770Notes

Reaction equation

HRID 1725770 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:19]>CO>[ClH:19].[ClH:19].[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17840015tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 132811914-(1H-Imidazol-2-yl)piperidine dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate (5.5 g) in methanol was saturated with HCl and the mixture was left standing overnight. Evaporation give the product in quantitative yield. 1H NMR (400 MHz, D2O): 7.29 (s, 2H), 3.51 (br. d, J=13 Hz, 2H), 3.47-3.40 (m, 1H), 3.12 (br. t, J=13 Hz, 2H), 2.29 (br. d, J=14 Hz, 2H), 2.04-1.92 (m, 21).

Workup

  1. waitthe mixture was left
  2. customEvaporation
  3. customgive the product in quantitative yield

Sources & evidence

ORD record
ord-73dc8929c73247ff81ff4ce59d50f92a
Source dataset
uspto-grants-2009_02
Patent number
US07491737B2

Reaction notes

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