HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazole → 4-(1,3-Thiazol-2-yl)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazole | HCID 9256 | — |
| Reactant | 4-(1H-Imidazol-2-yl)piperidine dihydrochloride | HCID 13281191 | — |
| Product | 4-(1,3-Thiazol-2-yl)piperidine hydrochloride | HCID 68727098 | — |
Reaction Steps
Prepared similarly as in the case of 4-(1H-imidazol-2-yl)piperidine dihydrochloride using 1,3-thiazole instead of 1-(diethoxymethyl)-1H-imidazole in Step A. 1H NMR (400 MHz, D2O): 8.24 (m, 1 H), 7.90(m, 1H), 3.77-3.68 (m, 1H), 3.57 (br. d, J=13 Hz, 2H), 3.19 (br. t, J=13 Hz, 2H), 2.42 (br. d, J=13 Hz, 21), 2.11-2.01 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491737B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-238570bed3714d9e8ace56ece2867932 |
| Source note | uspto-grants-2009_02 |