Thiazole → 4-(1,3-Thiazol-2-yl)piperidine hydrochloride

HRID 1725771Notes

Reaction equation

HRID 1725771 reaction equation
[ClH:1].Cl.[NH:3]1[CH:7]=[CH:6]N=[C:4]1[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[S:14]1C=CN=C1>>[ClH:1].[S:14]1[CH:6]=[CH:7][N:3]=[C:4]1[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 9256ThiazoleHCID 132811914-(1H-Imidazol-2-yl)piperidine dihydrochloride

Product 1

HCID 687270984-(1,3-Thiazol-2-yl)piperidine hydrochloride

Procedure

Prepared similarly as in the case of 4-(1H-imidazol-2-yl)piperidine dihydrochloride using 1,3-thiazole instead of 1-(diethoxymethyl)-1H-imidazole in Step A. 1H NMR (400 MHz, D2O): 8.24 (m, 1 H), 7.90(m, 1H), 3.77-3.68 (m, 1H), 3.57 (br. d, J=13 Hz, 2H), 3.19 (br. t, J=13 Hz, 2H), 2.42 (br. d, J=13 Hz, 21), 2.11-2.01 (m, 2H).

Sources & evidence

ORD record
ord-238570bed3714d9e8ace56ece2867932
Source dataset
uspto-grants-2009_02
Patent number
US07491737B2

Reaction notes

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