Hydrochloric Acid → HCID 68853956, compound

Participants

Reaction Steps

In an analogous manner to Example 135, step 4,1-{2-piperazin-1-yl-1-[3′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl 4-{2-(1-hydroxycyclohexyl)-2-[3′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]ethyl}piperazine-1-carboxylate. MS (ES) m/z 449.3 ([M+H]+); HRMS: calcd for C25H31F3N2O2.2.00 HCl, 520.1871; found (ESI), 449.2389.

Provenance & Evidence