Hydrochloric Acid → HCID 68853956, compound

HRID 1725793Notes

Reaction equation

[OH:1][C:2]1([CH:8]([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]([F:39])([F:38])[F:37])[CH:30]=3)=[CH:25][CH:24]=2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[ClH:40]>>[ClH:40].[ClH:40].[N:10]1([CH2:9][CH:8]([C:2]2([OH:1])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]([F:39])([F:38])[F:37])[CH:30]=3)=[CH:25][CH:24]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68851999HCID 68851999, compound

Product 1

HCID 68853956HCID 68853956, compound

Procedure

In an analogous manner to Example 135, step 4,1-{2-piperazin-1-yl-1-[3′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl 4-{2-(1-hydroxycyclohexyl)-2-[3′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]ethyl}piperazine-1-carboxylate. MS (ES) m/z 449.3 ([M+H]+); HRMS: calcd for C25H31F3N2O2.2.00 HCl, 520.1871; found (ESI), 449.2389.

Sources & evidence

ORD record: ord-4a6cd49e50844bdc9b07fe32368d8fe3
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07491723B2

Reaction notes

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