HCID 68853646, compound → HCID 68853712, compound

HRID 1725809Notes

Reaction equation

HRID 1725809 reaction equation
[ClH:1].Cl.[CH2:3]([C@H]1N(C)CCN(C2CCCC[C@@]2(C(C2C=CC=C(OC(F)(F)F)C=2)C)O)C1)C.Cl.Cl.[CH2:34]([CH:36]1[NH:41][CH2:40][CH2:39][N:38]([CH2:42][C@@H:43]([C:55]2([OH:61])[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]2)[C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([O:50][C:51]([F:54])([F:53])[F:52])[CH:45]=2)[CH2:37]1)[CH3:35]>>[ClH:1].[ClH:1].[CH2:34]([C@H:36]1[N:41]([CH3:3])[CH2:40][CH2:39][N:38]([CH2:42][C@@H:43]([C:55]2([OH:61])[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]2)[C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([O:50][C:51]([F:53])([F:54])[F:52])[CH:45]=2)[CH2:37]1)[CH3:35]

Participants

3

Reactant 2

HCID 68853646HCID 68853646, compoundHCID 86599952HCID 86599952, compound

Product 1

HCID 68853712HCID 68853712, compound

Procedure

In an analogous manner to Example 24, 1-{(1S)-2-[(3R)-3-ethyl-4-methylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethylcyclohexanol dihydrochloride was prepared from 1-{(1S)-2-(3-ethylpiperazin-1-yl)-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol (See Example 350). HRMS: calcd for C22H33F3N2O2+H+, 415.25669; found (ESI, [M+H]+), 415.2563.

Sources & evidence

ORD record
ord-2f01fba1d8234a5ab88ea9216136f6cd
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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