HCID 57934922, compound → HCID 86599954, compound

HRID 1725810Notes

Reaction equation

HRID 1725810 reaction equation
[ClH:1].Cl.C[C@H]1N[C@@H](C)CN([CH2:11][C@@H:12]([C:24]2([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)C1.[CH3:31][C@H:32]1[NH:37][C@@H:36]([CH3:38])[CH2:35][N:34](C(=O)[C@@H](C2(O)CCCCC2)C2C=CC=C(OC(F)(F)F)C=2)[CH2:33]1>CO>[ClH:1].[ClH:1].[CH3:38][C@H:36]1[NH:37][C@@H:32]([CH3:31])[CH2:33][N:34]([CH:25]2[CH2:26][CH2:27][CH2:28][CH2:29][C@@:24]2([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:21])([F:23])[F:22])[CH:14]=2)[CH3:11])[OH:30])[CH2:35]1

Participants

4

Reactant 2

HCID 57934922HCID 57934922, compoundHCID 68854367HCID 68854367, compound

Product 1

HCID 86599954HCID 86599954, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to Example 1, step 2, 1-{(1S)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from 1-{(1R)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-oxo-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol. MS (ESI) m/z 401; HRMS: calcd for C21H31F3N2O2+H+, 401.24104; found (ESI, [M+H]+), 401.2418. [α]D25=−10° (c=0.01 g/mL, MeOH); CD=+@268 nm.

Sources & evidence

ORD record
ord-b303776ba6734b9385ab059d2c0a6ad6
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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