HCID 57934922, compound → HCID 86599954, compound

Participants

Reaction Steps

In an analogous manner to Example 1, step 2, 1-{(1S)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from 1-{(1R)-2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-oxo-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol. MS (ESI) m/z 401; HRMS: calcd for C21H31F3N2O2+H+, 401.24104; found (ESI, [M+H]+), 401.2418. [α]D25=−10° (c=0.01 g/mL, MeOH); CD=+@268 nm.

Provenance & Evidence