HCID 68855556, compound → HCID 86599958, compound

HRID 1725814Notes

Reaction equation

HRID 1725814 reaction equation
[ClH:1].Cl.N[C@@H]1CCN([CH2:9][CH:10]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)C1.C(OC(=O)[NH:35][C@@H:36]1[CH2:40][CH2:39][N:38](C(=O)C(C2(O)CCCCC2)C2C=CC=C(OC(F)(F)F)C=2)[CH2:37]1)(C)(C)C>>[ClH:1].[ClH:1].[NH2:35][C@@H:36]1[CH2:40][CH2:39][N:38]([CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27][C:22]2([CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)[CH3:9])[OH:28])[CH2:37]1

Participants

3

Reactant 2

HCID 68855556HCID 68855556, compoundHCID 86600330HCID 86600330, compound

Product 1

HCID 86599958HCID 86599958, compound

Procedure

In an analogous manner to Example 1, step 2, 1-{2-[(3R)-3-aminopyrrolidin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl((3R)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl)carbamate. MS (ESI) m/z 373; HRMS: calcd for C19H27F3N2O2+H+, 373.20974; found (ESI, [M+H]+), 373.2097.

Sources & evidence

ORD record
ord-5ca092492ba7407d80c237ae1b61bb64
Source dataset
uspto-grants-2009_02
Patent number
US07491723B2

Reaction notes

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