反应详情

Next, 6 N hydrochloric acid (8 ml) was added to ethyl 2-acetyl-3-(4-pyridyl)propionate (1.20 g, 4.81 mmol), and the mixture was refluxed for 1.5 hours. The reaction mixture was concentrated under reduced pressure, 2-propanol (10 ml) was added to the concentrate, and the whole was concentrated under reduced pressure again. Ethyl acetate was added to the resulting solid, and the solid was filtered off to give 0.79 g (89%) of 4-(4-pyridyl)-2-butanone as a pale yellow solid.

1. temperaturethe mixture was refluxed for 1.5 hours
2. concentrationThe reaction mixture was concentrated under reduced pressure, 2-propanol (10 ml)
3. additionwas added to the concentrate
4. concentrationthe whole was concentrated under reduced pressure again
5. additionEthyl acetate was added to the resulting solid
6. filtrationthe solid was filtered off