反应详情

温度

50 °C

A mixture of Example 1B (11.7 g, 66.9 mmol) in 1M NaOH (300 mL) was treated dropwise with 30% aqueous hydrogen peroxide (300 mL), heated to 50° C. for 30 minutes, cooled to room temperature, and filtered. The filtrate was adjusted to pH 4 with concentrated HCl, cooled to 4° C., and filtered. The filter cake was dried under vacuum to provide the desired product (4.46 g). MS (ESI(−)) m/e 164 (M−H)−.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. temperaturecooled to 4° C.
4. filtrationfiltered
5. customThe filter cake was dried under vacuum