HCID 68866057, compound → HCID 68982389, compound

HRID 1725965Notes

Reaction equation

HRID 1725965 reaction equation
[CH2:1]([O:3][C:4]1[C:13]([CH:14]=[CH2:15])=[CH:12][CH:11]=[C:10]([NH:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[C:5]=1[C:6]([O:8][CH3:9])=[O:7])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4]1[C:13]([CH2:14][CH3:15])=[CH:12][CH:11]=[C:10]([NH:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)(=[O:18])=[O:19])[C:5]=1[C:6]([O:8][CH3:9])=[O:7])[CH3:2]

Participants

4

Reactant 1

HCID 68866057HCID 68866057, compound

Product 1

HCID 68982389HCID 68982389, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of Example 388A (66 mg, 0.15 mmol) in methanol was treated with 10% Pd/C (50 mg) and stirred under a hydrogen atmosphere overnight at room temperature. Filtration and evaporation of the solvent gave the desired product.

Workup

  1. filtrationFiltration and evaporation of the solvent

Sources & evidence

ORD record
ord-46c4e59db2934ab29eaddf755d16dbeb
Source dataset
uspto-grants-2009_02
Patent number
US07491718B2

Reaction notes

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