反应详情

Methyl 2-amino-1-naphthoate (0.5 g, 2.4 mmol) in chloroform (5 mL) and DMF (1 mL) was treated with bromine (0.125 mL, 2.4 mmol) for 30 minutes, concentrated, and dissolved in ethyl acetate. The organic layer was washed with NaHCO3 (3×), brine (3×) and water (3×), dried (Na2SO4), filtered, and concentrated to provide the desired product (0.69 g). MS (DCI) m/e 284, 286 (M+H)+.

1. concentrationconcentrated
2. dissolutiondissolved in ethyl acetate
3. washThe organic layer was washed with NaHCO3 (3×), brine (3×) and water (3×)
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated