Trifluoroacetic acid → HCID 68866001, compound

HRID 1725991Notes

Reaction equation

HRID 1725991 reaction equation
C([O:5][C:6](=[O:33])/[CH:7]=[CH:8]/[C:9]1[C:10]([NH:23][S:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:26])=[O:25])=[C:11]([C:19]([O:21][CH3:22])=[O:20])[C:12]2[CH2:13][CH2:14][CH2:15][CH2:16][C:17]=2[CH:18]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:22][O:21][C:19]([C:11]1[C:12]2[CH2:13][CH2:14][CH2:15][CH2:16][C:17]=2[CH:18]=[C:9](/[CH:8]=[CH:7]/[C:6]([OH:33])=[O:5])[C:10]=1[NH:23][S:24]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)(=[O:25])=[O:26])=[O:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68865402HCID 68865402, compound

Product 1

HCID 68866001HCID 68866001, compoundYield 105.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of Example 476C (0.12 g, 0.25 mmol) in CH2Cl2 (3 mL) was treated with TFA (6 mL), stirred for 2 hours, and diluted with CH2Cl2. The organic layer was washed with 1M NaOH and brine (200 mL), dried (MgSO4), filtered, and concentrated to provide the desired product (0.11 g). MS (DCI) m/e 416 (M+H)+.

Workup

  1. washThe organic layer was washed with 1M NaOH and brine (200 mL)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-789802295641475488dc8b9e84db6281
Source dataset
uspto-grants-2009_02
Patent number
US07491718B2

Reaction notes

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