4-(Trifluoromethyl)phenol → 3-(4-Trifluoromethylphenoxy)dihydrofuran-2-one

HRID 1726028Notes

Reaction equation

HRID 1726028 reaction equation
Br[CH:2]1[CH2:7][CH2:6][O:5][C:3]1=[O:4].[F:8][C:9]([F:18])([F:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1>>[F:8][C:9]([F:17])([F:18])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH:2]2[CH2:7][CH2:6][O:5][C:3]2=[O:4])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 678744-(Trifluoromethyl)phenolHCID 954632(3H)-Furanone, 3-bromodihydro-

Product 1

HCID 114251083-(4-Trifluoromethylphenoxy)dihydrofuran-2-oneYield 46%

Procedure

The compound is prepared according to the experimental procedure described in Preparation 1, starting with α-bromo-γ-butyrolactone (6.7 g, 0.040 mol) and 4-trifluoromethylphenol (5.0 g, 0.031 mol) to give 3.51 g of the expected compound in the form of a white powder.

Workup

  1. customThe compound is prepared
  2. customdescribed in Preparation 1

Sources & evidence

ORD record
ord-c82ee625d54847c8a6a76e9928203bc3
Source dataset
uspto-grants-2009_02
Patent number
US07491747B2

Reaction notes

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