Diethyl Ether → HCID 66756024, compound

HRID 1726033Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][NH:4][CH:5]([C:9]1[O:10][C:11]2[C:16]([C:17](=[O:26])[C:18]=1[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:15][CH:14]=[C:13]([Cl:27])[CH:12]=2)[CH:6]([CH3:8])[CH3:7].C(N(CC)CC)C.[C:35]1([CH3:42])[CH:40]=[CH:39]C(Cl)=[CH:37][CH:36]=1.CC[O:45][CH2:46][CH3:47]>C(Cl)Cl>[CH2:19]([C:18]1[C:17](=[O:26])[C:16]2[C:11](=[CH:12][C:13]([Cl:27])=[CH:14][CH:15]=2)[O:10][C:9]=1[CH:5]([NH:4][CH2:3][CH2:2][NH:1][C:46](=[O:45])[C:47]1[CH:39]=[CH:40][C:35]([CH3:42])=[CH:36][CH:37]=1)[CH:6]([CH3:7])[CH3:8])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

Conditions

Temperature: 0 °C

Procedure

To a cooled (0° C.) solution of 2-[1-(2-amino-ethylamino)-2-methyl-propyl]-3-benzyl-7-chloro-chromen-4-one (4.1 g, 11 mmol) and triethylamine (2.2 mL, 17 mmol) in methylene chloride (100 mL) was added a solution of p-toluyl chloride (1.7 g 11 mmol) in methylene chloride (20 mL). The reaction was maintained at 0° C. for 2 hours, at which time it as diluted with ether (250 mL). The resultant solution was washed with 1 N hydrogen chloride (2×200 mL), saturated sodium bicarbonate (200 mL) and brine (150 mL), dried over magnesium sulfate, and concentrated. The residue was purified by flash chromatography (0→60% ethyl acetate/hexanes) to (give 2.8 g, (50%) of the title compound. MS(ES+) m/z 503 [M+H]+.

Workup

washThe resultant solution was washed with 1 N hydrogen chloride (2×200 mL), saturated sodium bicarbonate (200 mL) and brine (150 mL)
dry with materialdried over magnesium sulfate
concentrationconcentrated
customThe residue was purified by flash chromatography (0→60% ethyl acetate/hexanes) to (give 2.8 g, (50%) of the title compound. MS(ES+) m/z 503 [M+H]+

Sources & evidence

ORD record: ord-c97993e1c0754aa082eac1391916765d
Source dataset: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07491746B2

Reaction notes

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