反应详情

温度

90 °C

10.5 ml of acetic anhydride are run into a solution of 7.14 g of 4-benzyloxy-2-methylphenylamine in 26 ml of toluene. The medium is heated to around 90° C. and 9.28 ml of tert-butyl nitrite are run in to the solution, dropwise. The reaction medium is heated at around 90° C. for two hours. The reaction crude is concentrated to dryness in a rotary evaporator. The solid is taken up in ethyl acetate and then filtered and rinsed with isopropyl ether. 3.41 g of 1-(5-benzyloxyindazol-1-yl)ethanone are collected.

1. temperatureThe reaction medium is heated at around 90° C. for two hours
2. customThe reaction crude
3. concentrationis concentrated to dryness in a rotary evaporator
4. filtrationfiltered
5. washrinsed with isopropyl ether
6. custom3.41 g of 1-(5-benzyloxyindazol-1-yl)ethanone are collected