HuagongsheHuagongshe Chemistry Print Report · For research reference only
Styrylboronic acid → 5-benzyloxy-3-((E)-styryl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Styrylboronic acid | HCID 5702628 | — |
| Reactant | 1H-Indazole-1-carboxylic acid, 3-iodo-5-(phenylmethoxy)-, 1,1-dimethylethyl ester | HCID 57562411 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | 5-benzyloxy-3-((E)-styryl)-1H-indazole | HCID 68844272 | 69% |
Reaction Steps
The compound, 5-benzyloxy-3-((E)-styryl)-1H-indazole is prepared according to procedure C, step Ib, using 300 mg of 5-benzyloxy-3-iodoindazole-1-carboxylic acid tert-butyl ester, 197 mg of E-phenylethenyl boronic acid, 192 mg of palladium tetrakistriphenylphosphine in suspension in 12 ml of dimethylformamide and 0.61 ml of a saturated sodium bicarbonate solution. The resulting crude product is treated as described hereinabove to obtain 150 mg of 5-benzyloxy-3-((E)-styryl)-1H-indazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491710B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-b6ef7486c40e4589ae9e8b4b47b65414 |
| Source note | uspto-grants-2009_02 |