Benzyl Alcohol → HCID 136056005, compound

HRID 1726066Notes

Reaction equation

HRID 1726066 reaction equation
[N+](C1C=CC([O:10][P:11]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)(=[O:31])[O:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][N:17]=[C:16]3[C:22]2[NH:23][C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)=CC=1)([O-])=O.CC=C(C)C.[CH2:43](O)[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1.N12CCCN=C1CCCCC2>ClCCl>[CH2:43]([O:10][P:11]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)(=[O:31])[O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[C:16]2[C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1

Participants

6

Reactant 4

HCID 244Benzyl AlcoholHCID 105532-Methyl-2-buteneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 136342066HCID 136342066, compound

Product 1

HCID 136056005HCID 136056005, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Phenylphosphonic acid 3-(1H-indol-2-yl)-1H-indazol-5-yl ester benzyl ester is prepared according to procedure F using 150 mg of phenyl-phosphonic acid 3-(1H-indol-2-yl)-1H-indazol-5-yl ester 4-nitrophenyl ester (prepared according to procedure F) in solution in 2 ml of dichloromethane stabilized with amylene, 310 μl of benzyl alcohol and 44 μl of 1,8-diazabicyclo[5.4.0]undec-7-ene. The reaction crude is purified by preparative LC/MS to obtain 16.9 mg of phenylphosphonic acid 3-(1H-indol-2-yl)-1-indazol-5-yl ester benzyl ester.

Workup

  1. customThe reaction crude
  2. customis purified by preparative LC/MS

Sources & evidence

ORD record
ord-6fdc550522684143bf2985b82fb4923e
Source dataset
uspto-grants-2009_02
Patent number
US07491710B2

Reaction notes

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