HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1726069Generated: November 1, 2026
Ammonium formate → 1-(5-hydroxy-1H-indazol-1-yl)-Ethanone
https://huagongshe.com/reaction/1726069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 1-(5-(Benzyloxy)-1H-indazol-1-yl)ethan-1-one | HCID 22567249 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(5-hydroxy-1H-indazol-1-yl)-Ethanone | HCID 22567048 | 91.9% |
Reaction Steps
A suspension of 939 mg of 1-(5-benzyloxyindazol-1-yl)ethanone, 1.33 g of ammonium formate and 939 mg of palladium-on-charcoal at 10% in 100 ml of absolute ethanol is heated at around 50° C. for about thirty minutes. When gas is no longer being given off, the catalyst is filtered through a paper filter and rinsed with absolute ethanol. The filtrate is concentrated under reduced pressure in a rotary evaporator to obtain 571.1 mg of 1-(5-hydroxyindazol-1-yl)ethanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07491710B2 |
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| Source dataset | uspto-grants-2009_02 |
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| ORD ID | ord-bcffd5197f7943bd91e554aebc28d76f |
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| Source note | uspto-grants-2009_02 |
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