HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → phenylphosphonic acid 1H-indazol-5-yl ester methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | phenylphosphonic acid 1-acetyl-1H-indazol-5-yl ester 4-nitrophenyl ester | HCID 57562494 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | phenylphosphonic acid 1H-indazol-5-yl ester methyl ester | HCID 57562461 | 10.4% |
Reaction Steps
Phenylphosphonic acid 1H-indazol-5-yl ester methyl ester is prepared according to procedure F using 219 mg of phenyl-phosphonic acid 1-acetyl-1H-indazol-5-yl ester 4-nitrophenyl ester, 5 ml of dichloromethane, 74.8 μl of 1,8-diazabicyclo[5.4.0]undec-7-ene and 202 μl of methanol. The crude is purified by flash chromatography on silica with a particle size of 35-70 μm. Eluent: cyclohexane then 80:20 cyclohexane/ethyl acetate to obtain 15 mg of phenylphosphonic acid 1H-indazol-5-yl ester methyl ester in the form of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491710B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-6d213b39f935484e95d9ca8ce41096a2 |
| Source note | uspto-grants-2009_02 |