反应详情

Phenylphosphonic acid 1H-indazol-5-yl ester methyl ester is prepared according to procedure F using 219 mg of phenyl-phosphonic acid 1-acetyl-1H-indazol-5-yl ester 4-nitrophenyl ester, 5 ml of dichloromethane, 74.8 μl of 1,8-diazabicyclo[5.4.0]undec-7-ene and 202 μl of methanol. The crude is purified by flash chromatography on silica with a particle size of 35-70 μm. Eluent: cyclohexane then 80:20 cyclohexane/ethyl acetate to obtain 15 mg of phenylphosphonic acid 1H-indazol-5-yl ester methyl ester in the form of a colorless oil.

1. customPhenylphosphonic acid 1H-indazol-5-yl ester methyl ester is prepared
2. customThe crude is purified by flash chromatography on silica with a particle size of 35-70 μm