HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → HCID 178502967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | phenylphosphonic acid 1H-indazol-5-yl ester methyl ester | HCID 57562461 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178502967 | HCID 178502967 | 71.1% |
Reaction Steps
Phenylphosphonic acid 3-iodo-1H-indazol-5-yl ester methyl ester is prepared according to procedure A using 76 mg of phenylphosphonic acid 1H-indazol-5-yl ester methyl ester, 134 mg of iodine and 30.6 mg of potassium hydroxide ground before hand in 3 ml of dimethylformamide. The crude is purified by flash chromatography on silica with a particle size of 15-35 μm. Eluent: ethyl acetate/cyclohexane 1:1 to obtain 77.6 mg of phenyl-phosphonic acid 3-iodo-1H-indazol-5-yl ester methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07491710B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-cfad7bf84572484588423c890c5e0f57 |
| Source note | uspto-grants-2009_02 |