反应详情

Phenylphosphonic acid 3-iodo-1H-indazol-5-yl ester methyl ester is prepared according to procedure A using 76 mg of phenylphosphonic acid 1H-indazol-5-yl ester methyl ester, 134 mg of iodine and 30.6 mg of potassium hydroxide ground before hand in 3 ml of dimethylformamide. The crude is purified by flash chromatography on silica with a particle size of 15-35 μm. Eluent: ethyl acetate/cyclohexane 1:1 to obtain 77.6 mg of phenyl-phosphonic acid 3-iodo-1H-indazol-5-yl ester methyl ester.

1. customPhenylphosphonic acid 3-iodo-1H-indazol-5-yl ester methyl ester is prepared
2. customThe crude is purified by flash chromatography on silica with a particle size of 15-35 μm