Hydrochloric Acid → HCID 178502965, compound

Participants

Reaction Steps

18.5 mg of [3-((E)-Styryl)-1H-indazol-5-yl]phosphonic acid dimethyl ester are dissolved in 500 μl of 1M sodium hydroxide solution in methanol. The medium is stirred at ambient temperature for 4 hours. 100 μl of 2N hydrochloric acid are added to the mixture, which is stirred for 15 min at ambient temperature. The organic phase is extracted with 3 ml of ethyl acetate. The solvent is evaporated off under vacuum in a centrifugal evaporator to obtain 18 mg of the title compound.

Provenance & Evidence