Hydrochloric Acid → HCID 178502965, compound

HRID 1726074Notes

Reaction equation

HRID 1726074 reaction equation
[CH3:1][O:2][P:3]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:6])[O:4]C.Cl>[OH-].[Na+].CO>[CH3:1][O:2][P:3]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2/[CH:16]=[CH:17]/[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:4])[OH:6]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178502975HCID 178502975, compound

Product 1

HCID 178502965HCID 178502965, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

18.5 mg of [3-((E)-Styryl)-1H-indazol-5-yl]phosphonic acid dimethyl ester are dissolved in 500 μl of 1M sodium hydroxide solution in methanol. The medium is stirred at ambient temperature for 4 hours. 100 μl of 2N hydrochloric acid are added to the mixture, which is stirred for 15 min at ambient temperature. The organic phase is extracted with 3 ml of ethyl acetate. The solvent is evaporated off under vacuum in a centrifugal evaporator to obtain 18 mg of the title compound.

Workup

  1. stirringis stirred for 15 min at ambient temperature
  2. extractionThe organic phase is extracted with 3 ml of ethyl acetate
  3. customThe solvent is evaporated off under vacuum in a centrifugal evaporator

Sources & evidence

ORD record
ord-f9b453d61efb463b847584f35665032a
Source dataset
uspto-grants-2009_02
Patent number
US07491710B2

Reaction notes

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