Ammonium formate → 3-[5-(2-diethylaminoethoxy)-1H-indol-2-yl]-1H-indazol-5-ol

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Reaction Steps

A suspension of 320 mg of {2-[2-(5-benzyloxy-1H-indazol-3-yl)-1H-indol-5-yloxy]ethyl}diethylamine, 32 mg of palladium-on-charcoal at 10%, and 180 mg of ammonium formate is irradiated in a Synthwave 402 microwave oven at atmospheric pressure for 35 minutes at 75° C. at 5% power, and then for 10 minutes at 20% power. The catalyst is filtered through a bed of celite, and the filtrate is evaporated under reduced pressure. The compound obtained is taken up in ethyl acetate (20 ml) and a saturated sodium bicarbonate solution (20 ml), separated by settling out, dried over magnesium sulfate and then evaporated under reduced pressure to obtain 115 mg of 3-[5-(2-diethylaminoethoxy)-1H-indol-2-yl]-1H-indazol-5-ol, which is characterized.

Provenance & Evidence