反应详情

A suspension of 320 mg of {2-[2-(5-benzyloxy-1H-indazol-3-yl)-1H-indol-5-yloxy]ethyl}diethylamine, 32 mg of palladium-on-charcoal at 10%, and 180 mg of ammonium formate is irradiated in a Synthwave 402 microwave oven at atmospheric pressure for 35 minutes at 75° C. at 5% power, and then for 10 minutes at 20% power. The catalyst is filtered through a bed of celite, and the filtrate is evaporated under reduced pressure. The compound obtained is taken up in ethyl acetate (20 ml) and a saturated sodium bicarbonate solution (20 ml), separated by settling out, dried over magnesium sulfate and then evaporated under reduced pressure to obtain 115 mg of 3-[5-(2-diethylaminoethoxy)-1H-indol-2-yl]-1H-indazol-5-ol, which is characterized.

1. customis irradiated in a Synthwave 402 microwave oven at atmospheric pressure for 35 minutes at 75° C. at 5% power
2. filtrationThe catalyst is filtered through a bed of celite
3. customthe filtrate is evaporated under reduced pressure
4. customThe compound obtained
5. customa saturated sodium bicarbonate solution (20 ml), separated
6. dry with materialdried over magnesium sulfate
7. customevaporated under reduced pressure