反应详情

A suspension of 1 g of 1-(5-benzyloxyindazol-1-yl)ethanone, 1.42 g of ammonium formate and 0.59 g of palladium-on-charcoal at 10% in ethanol is refluxed for 16 hours. After returning to 20° C., the reaction mixture is filtered through a bed of celite and the filtrate is evaporated under reduced pressure. The crude compound thus obtained is triturated in 10 ml of diisopropyl ether and then filtered and dried under reduced pressure to obtain 400 mg of 1-(5-hydroxy-indazol-1-yl)-ethanone, which is characterized.

1. temperatureis refluxed for 16 hours
2. customAfter returning to 20° C.
3. filtrationthe reaction mixture is filtered through a bed of celite
4. customthe filtrate is evaporated under reduced pressure
5. customThe crude compound thus obtained
6. customis triturated in 10 ml of diisopropyl ether
7. filtrationfiltered
8. customdried under reduced pressure