tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68972754, compound

HRID 1726150Notes

Reaction equation

HRID 1726150 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl.[CH3:16][S:17]([C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)(=[O:19])=[O:18]>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:24][C:23]2[CH:22]=[CH:21][C:20]([S:17]([CH3:16])(=[O:19])=[O:18])=[CH:26][CH:25]=2)[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 27351804-(Methylsulfonyl)aniline hydrochloride

Product 1

HCID 68972754HCID 68972754, compoundYield 50%

Procedure

Using general procedure A, 1-Boc-4-piperidone (2.01 g, 10.09 mmol) and 4-(methanesulfonyl)aniline hydrochloride (1.69 g, 8.13 mmol) afforded 4-(4-methanesulfonyl-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester as a white solid (1.44 g, 50%).

Sources & evidence

ORD record
ord-42b7b0decc7b4b52982b46bf9fd32b9e
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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