tert-Butyl 4-oxopiperidine-1-carboxylate → 4-[4-(2-Methoxy-ethoxy)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1726177노트

반응식

HRID 1726177 반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1.[C:13]([N:20]1[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]1)([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]>>[C:16]([O:15][C:13]([N:20]1[CH2:25][CH2:24][CH:23]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:7][CH:8]=2)[CH2:22][CH2:21]1)=[O:14])([CH3:19])([CH3:17])[CH3:18]

참가 물질

3

반응물 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 38798854-(2-Methoxyethoxy)aniline

생성물 1

HCID 689704944-[4-(2-Methoxy-ethoxy)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester수율 86.9%

실험 절차

Using general procedure A, 4-(2-methoxy-ethoxy)-phenylamine (Ishidate; Maruyoma, Chem. Abstr., 1952, 8810) (1.15 g, 6.84 mmol) and 1-Boc-4-piperidone (1.36 g, 6.83 mmol) afforded 4-[4-(2-methoxy-ethoxy)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester (2.08 g, 86%).

출처 및 근거

ORD 기록
ord-0f80fc09251d4a52839540336deeb0f3
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491735B2

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