Hydrochloric Acid → HCID 86602132, compound

Participants

Reaction Steps

To a solution of COMPOUND 111 (880 mg, 1.59 mmol) in MeOH (10 mL) was added 6N HCl (20 mL) and the solution was stirred at room temperature for 18 hours and heated at 40° C. for 3 hours to give 4,6-dimethyl-pyrimidine-5-carboxylic acid (3-{4-[(4-amino-phenyl)-(3-cyano-benzyl)-amino]-piperidin-1-yl}-butyl)-amide as a white solid (813 mg, 100%) following a basic work-up.

Provenance & Evidence