Hydrochloric Acid → HCID 86602132, compound

HRID 1726207Notes

Reaction equation

HRID 1726207 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]#[N:41])[CH:35]=2)[CH:12]2[CH2:17][CH2:16][N:15]([CH:18]([CH3:32])[CH2:19][CH2:20][NH:21][C:22]([C:24]3[C:25]([CH3:31])=[N:26][CH:27]=[N:28][C:29]=3[CH3:30])=[O:23])[CH2:14][CH2:13]2)=[CH:7][CH:6]=1)(=O)C.Cl>CO>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([N:11]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([C:40]#[N:41])[CH:35]=2)[CH:12]2[CH2:17][CH2:16][N:15]([CH:18]([CH3:32])[CH2:19][CH2:20][NH:21][C:22]([C:24]3[C:29]([CH3:30])=[N:28][CH:27]=[N:26][C:25]=3[CH3:31])=[O:23])[CH2:14][CH2:13]2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57563239HCID 57563239, compound

Product 1

HCID 86602132HCID 86602132, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of COMPOUND 111 (880 mg, 1.59 mmol) in MeOH (10 mL) was added 6N HCl (20 mL) and the solution was stirred at room temperature for 18 hours and heated at 40° C. for 3 hours to give 4,6-dimethyl-pyrimidine-5-carboxylic acid (3-{4-[(4-amino-phenyl)-(3-cyano-benzyl)-amino]-piperidin-1-yl}-butyl)-amide as a white solid (813 mg, 100%) following a basic work-up.

Workup

  1. temperatureheated at 40° C. for 3 hours

Sources & evidence

ORD record
ord-b88216e9d588498fa83e4cb920544abe
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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