2-(3-Oxobutyl)isoindoline-1,3-dione → HCID 68971694, compound

HRID 1726271Notes

Reaction equation

HRID 1726271 reaction equation
[F:1][C:2]1[C:10]2[O:9][C:8]([CH:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=3)[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.O=[C:28]([CH3:42])[CH2:29][CH2:30][N:31]1C(=O)C2C(=CC=CC=2)C1=O>>[F:1][C:2]1[C:10]2[O:9][C:8]([CH:21]3[CH2:22][CH2:23][N:24]([CH:28]([CH3:42])[CH2:29][CH2:30][NH2:31])[CH2:25][CH2:26]3)([C:11]3[CH:12]=[CH:13][C:14]([C:17]([F:18])([F:20])[F:19])=[CH:15][CH:16]=3)[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2907282-(3-Oxobutyl)isoindoline-1,3-dioneHCID 68972421HCID 68972421, compound

Product 1

HCID 68971694HCID 68971694, compound

Procedure

Using general procedure B with the above amine (18 mg, 0.049 mmol) and 2-(3-oxo-butyl)-isoindole-1,3-dione (21 mg, 0.098 mmol) and then using general procedure D afforded 3-{4-[4-fluoro-2-(4-trifluoromethyl-phenyl)-benzo[1,3]dioxol-2-yl]-piperidin-1-yl}-butylamine as a white solid (11 mg, 52% over 2 steps).

Sources & evidence

ORD record
ord-5b10f78b99da41ef9df697d4a8ba270c
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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