4-(Trifluoromethoxy)aniline → HCID 68974486, compound

HRID 1726292Notes

Reaction equation

HRID 1726292 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C@H:8]([CH3:12])[CH2:9][C:10]#[N:11])[CH2:4][CH2:3]1.[F:13][C:14]([F:24])([F:23])[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1>>[F:13][C:14]([F:23])([F:24])[O:15][C:16]1[CH:17]=[CH:18][C:19]([NH:20][CH:2]2[CH2:7][CH2:6][N:5]([C@H:8]([CH3:12])[CH2:9][C:10]#[N:11])[CH2:4][CH2:3]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 68972438(betaR)-beta-Methyl-4-oxo-1-piperidinepropanenitrile

Product 1

HCID 68974486HCID 68974486, compoundYield 113%

Procedure

Using general procedure A, (R)-3-(4-oxo-piperidin-1-yl)-butyronitrile (2.0 g, 12 mmol) and 4-(trifluoromethoxy)aniline (1.34 mL, 10.0 mmol) gave (R)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-butyronitrile as a pale yellow solid (3.7 g, 94%).

Sources & evidence

ORD record
ord-d5dcb8a2a74c4d2b81f8a916d57bb792
Source dataset
uspto-grants-2009_02
Patent number
US07491735B2

Reaction notes

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