1-(2-Pyridyl)piperazine → HCID 15942648, compound

HRID 1726370Notes

Reaction equation

HRID 1726370 reaction equation
[N:1]1C=CC=CC=1N1CCNCC1.[CH3:13][CH:14]([NH:28][C:29]([C:31]1[O:35][C:34]([C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=2)=[N:33][C:32]=1[CH2:43][CH2:44][CH3:45])=[O:30])[CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:18][CH2:17]1>>[NH2:1][C:24]1[N:23]=[C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:15][CH:14]([NH:28][C:29]([C:31]3[O:35][C:34]([C:36]4[CH:37]=[CH:38][C:39]([F:42])=[CH:40][CH:41]=4)=[N:33][C:32]=3[CH2:43][CH2:44][CH3:45])=[O:30])[CH3:13])[CH2:21][CH2:20]2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 46231661HCID 46231661, compound2×

Product 1

HCID 15942648HCID 15942648, compound

Procedure

Similarly, following the procedure set forth in Example 1(B-G) substituting 1-pyridin-2-yl-piperazine for (intermediate “Ia”), 2-(4-fluorophenyl)-4-propyl-oxazole-5-carboxylic acid [1-methyl-2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-amide (compound 24) was prepared.

Sources & evidence

ORD record
ord-754ff3fae2a047098ae70ac9c4ee0548
Source dataset
uspto-grants-2009_02
Patent number
US07491821B2

Reaction notes

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