反应详情

温度

25 °C

To a 25° C. solution of aniline (1 eq) in anhydrous THF (2 mL per imnol aniline) was added polymer bound pyridine (1.5 eq) followed by 2-methyl-benzoyl chloride (1 eq). The mixture was stirred at 25° C. for 12-24 h. The reaction mixture was filtered and the filtrate concentrated in vacuo. Hexane was added to the residue and the resulting precipitate was collected by filtration, resulting in a white solid (yield 65%). LC/MS (M+H)+ m/z 266. The crude material was used without further purification.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate concentrated in vacuo
3. additionHexane was added to the residue
4. filtrationthe resulting precipitate was collected by filtration