反应详情

温度

25 °C

To neat amide (58), at 0° C., was added chlorosulfonic acid (5 eq) dropwise. The temperature was allowed to warm to 25° C. and then heated at 70° C. for 45 minutes. After cooling to 25° C., the reaction mixture was poured into ice water, and the resultant precipitate was collected by filtration to give the title compound as a solid. The product (mixture of regioisomers) was used without further purification.

1. temperatureheated at 70° C. for 45 minutes
2. temperatureAfter cooling to 25° C.
3. filtrationthe resultant precipitate was collected by filtration