HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1726522Generated: October 31, 2026
Chlorosulfonic acid → HCID 59718023, compound
https://huagongshe.com/reaction/1726522
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Benzamide, 2-methyl-N-(5,6,7,8-tetrahydro-1-naphthalenyl)- | HCID 796063 | — |
| Product | HCID 59718023 | HCID 59718023 | — |
Reaction Steps
To neat amide (58), at 0° C., was added chlorosulfonic acid (5 eq) dropwise. The temperature was allowed to warm to 25° C. and then heated at 70° C. for 45 minutes. After cooling to 25° C., the reaction mixture was poured into ice water, and the resultant precipitate was collected by filtration to give the title compound as a solid. The product (mixture of regioisomers) was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07491827B2 |
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| Source dataset | uspto-grants-2009_02 |
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| ORD ID | ord-fbf37ce7e1f44384bb5a52eafc490263 |
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| Source note | uspto-grants-2009_02 |
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